Have I mentioned how much I love Tysabri? I have? Well, pretend that you have not heard this before then or go pluck your nose hairs for a few minutes while I rhapsodize about Tysabri. I have been on 3 different meds for my MS before Tysabri (Tie-sob-ree), Avonex, Copaxone, and Novantrone. Avonex was about as effective as water for me. My Ms is too aggressive and it did nothing but make me sick, tired and more depressed--not a good thing. Plus the IM(intra-muscular) shots HURT! After 6 months and 3 attacks my neuro switched me to Copaxone, which I loved almost as much at Tysabri. I did my own shots with my own little Auto Injector and sub-q (sub-cutaneous, just under the skin) does not hurt, in fact a lot of times I didn't feel a thing. The only down side to Copaxone is the itchy injection sites and it has the least reduction in relapses; but no depression or sickness. Novantrone was a hideous experience; it is a chemotherapy. I think that says it all. I was stuck in the house for 2 weeks after because I could not risk getting sick and I lost no hair--what a rip-off! But Tysabri is the BEST! I have not felt this good since before I was diagnosed. There is no depression, it is once a month (you can go a week early or a week later depending on how long it lasts. I go every 3 weeks because I burn through it faster and start getting attack-y after 3 weeks.) it has helped with my fatigue and walking--in short I feel alive again! It is done IV, but that is not a big deal. I have not had an attack since starting it this last February--and that is a record for me; before this my longest time attack-free was 5 months. It doesn't cause depression, or make me sick, in fact I can't think of a down side to it. Wait, I thought of one. They say it is about $27,000 a year, but that is the med alone. Once you add in having to go into an infusion center and all the charges that entails it comes to more like $50,000. A hefty price tag but worth it--it makes life worth living for me again.